Amyloid Beta has been studied for years for its role in Alzheimer disease. Insulin and Amylin are hormones that are co-secreted from pancreatic beta cells and have been known to play a role in creating amyloid plaques in the brain. The normal role of amylin and insulin in the brain are to regulate satiety and gastric emptying. It is unknown as to how amyloid beta grows around the nerve cells in the brain to disrupt brain activity. Studies have shown a link between amyloid beta, blocking insulin and amylin receptors reducing its affinity. The presence of amylin and insulin in Alzheimer’s disease brains will enable the connection that the two proteins have on amyloid plaque development. This study analyzes the protein expression levels of amylin and insulin in Alzheimer’s disease brains. ELISA assays were conducted to detect the presence and activity levels of both amylin and insulin. Knowing the effect of amylin and insulin in the development of amyloid plaques can help to further understand the formation of amyloid plaque in the development of Alzheimer disease.
