All Abstracts

There is a known link between Diabetes, specifically type two, and the development of Alzheimer's Disease. While studies have not yet been able to determine whether greater amounts of insulin cause Alzheimer’s Disease, the idea that this phenomenon may occur has inspired us to explore how UCP2 af...

Prostate cancer, a multifocal disease, is initially responsive to therapies that inhibit androgen receptor (AR) signaling, but the disease eventually progresses to an androgen-independent or refractory state. Understanding and modulating AR function may be essential to the development of new treatme...

Amylin is a protein that is co-secreted from pancreatic beta cells alongside insulin and has been shown to cross the blood-brain barrier and impact the formation of amyloid plaques. The normal function of amylin in the brain is directly correlated to metabolism because amylin is considered a satiety...

Amylin is a fibrillogenic protein co-secreted with insulin from pancreatic beta cells. Amylin has been shown to function in metabolism through its influence on glucose homeostasis. It has also been proposed to have an impact on amyloid beta, a major component of the amyloid plaques found in Alzheime...

There is recent evidence that suggests that cancer development and progression may be influenced by an interplay between cancer cells and the surrounding tumor microenvironment, which includes extracellular matrix (ECM) components. Understanding changes in human prostate cancer cell progression and ...

The glycolytic astrocyte possesses a high redox and xenobiotic buffering capacity through glutathione (GSH), neutralizing many forms of reactive oxygen species (ROS) and excreting xenobiotics through GSH-xenobiotic adducts back into the blood stream. Astrocytes are the first line of defense against ...

The nucleoside analog, 3’-azido-3’-deoxythymidine (Zidovudine, AZT), is a major component in the first-line therapy for HIV-1 infection worldwide. HIV-1 infected patients treated long-term with AZT often become resistant, and different mechanisms have been proposed. Two possible mechanisms are ...

Amyloid Beta has been studied for years for its role in Alzheimer disease. Insulin and Amylin are hormones that are co-secreted from pancreatic beta cells and have been known to play a role in creating amyloid plaques in the brain. The normal role of amylin and insulin in the brain are to regulate s...